H-2复合体在体内诱导T辅助细胞中的作用。II. 受I-A和I-A/E决定簇限制的T细胞离散亚群的阴性选择
Role of the H-2 complex in induction of T helper cells in vivo. II Negative selection of discrete subgroups of T cells restricted by I-A and I-A/E determinants.
作者信息
Sprent J, Alpert B
出版信息
J Exp Med. 1981 Apr 1;153(4):823-31. doi: 10.1084/jem.153.4.823.
Abstract
Previous studies have shown that negative selection of T cells to sheep erythrocytes (SRC) after adoptive transfer to irradiated mice requires a sharing of H-2 determinants between the donor T cells and the selection hosts. This paper examines which part of the H-2 complex controls selection. The results show that, in the case of T cells of the H-2k haplotype, complete selection occurs with donor host matching limited to the I-A through I-E subregions of the H-2 complex. Selection to SRC was partial in I-A compatible, I-E incompatible hosts, minimal or not detectable in I-A incompatible, I-E compatible hosts, but near-complete in hosts matched at both the I-A and I-E subregions. Consecutive selection in hosts matched solely at (a) the I-A subregion and (b) the I-E subregion led to incomplete selection. From these and other findings it is argued that H-2k T cells comprise a mixture of T cells restricted by I-A and I-A/E hybrid molecules.
摘要
先前的研究表明，将T细胞过继转移到受照射小鼠后，T细胞对绵羊红细胞（SRC）的阴性选择需要供体T细胞与选择宿主之间共享H-2决定簇。本文研究了H-2复合体的哪一部分控制选择。结果表明，对于H-2k单倍型的T细胞，当供体与宿主在H-2复合体的I-A至I-E亚区相匹配时，会发生完全选择。在I-A相容、I-E不相容的宿主中对SRC的选择是部分的，在I-A不相容、I-E相容的宿主中选择最少或无法检测到，但在I-A和I-E亚区均匹配的宿主中接近完全选择。仅在（a）I-A亚区和（b）I-E亚区匹配的宿主中进行连续选择会导致不完全选择。从这些以及其他发现可以推断，H-2k T细胞包含受I-A和I-A/E杂交分子限制的T细胞混合物。
相似文献
1
Role of the H-2 complex in induction of T helper cells in vivo. II Negative selection of discrete subgroups of T cells restricted by I-A and I-A/E determinants.H-2复合体在体内诱导T辅助细胞中的作用。II. 受I-A和I-A/E决定簇限制的T细胞离散亚群的阴性选择
J Exp Med. 1981 Apr 1;153(4):823-31. doi: 10.1084/jem.153.4.823.
2
Role of the H-2 complex in induction of T helper cells in vivo. III. Contribution of the I-E subregion to restriction sites recognized by I-A/E-restricted T cells.H-2复合体在体内诱导T辅助细胞中的作用。III. I-E亚区对I-A/E限制性T细胞识别的限制位点的贡献。
J Exp Med. 1982 Feb 1;155(2):548-56. doi: 10.1084/jem.155.2.548.
3
Effects of blocking helper T cell induction in vivo with anti-Ia antibodies. Possible role of I-A/E hybrid molecules as restriction elements.用抗Ia抗体在体内阻断辅助性T细胞诱导的作用。I-A/E杂交分子作为限制元件的可能作用。
J Exp Med. 1980 Oct 1;152(4):996-1010. doi: 10.1084/jem.152.4.996.
4
Role of the H-2 complex in induction of T helper cells in vivo. I. Antigen-specific selection of donor T cells to sheep erythrocytes in irradiated mice dependent upon sharing of H-2 determinants between donor and host.H-2复合体在体内诱导T辅助细胞中的作用。I. 照射小鼠体内供体T细胞对绵羊红细胞的抗原特异性选择取决于供体与宿主之间H-2决定簇的共享。
J Exp Med. 1978 Aug 1;148(2):478-89. doi: 10.1084/jem.148.2.478.
5
Features of cells controlling H-2-restricted presentation of antigen to T helper cells in vivo.
J Immunol. 1980 Nov;125(5):2089-96.
6
Features of T cells causing H-2-restricted lethal graft-vs.-host disease across minor histocompatibility barriers.跨越次要组织相容性屏障引发H-2限制性致死性移植物抗宿主病的T细胞特征。
J Exp Med. 1982 Mar 1;155(3):872-83. doi: 10.1084/jem.155.3.872.
7
Negative selection of discrete subgroups of T helper cells restricted by determinants present on I-A and I-A/E molecules.由I-A和I-A/E分子上存在的决定簇所限制的T辅助细胞离散亚群的阴性选择。
Adv Exp Med Biol. 1982;149:623-7. doi: 10.1007/978-1-4684-9066-4_86.
8
Antigen-dependent, H-2-restricted cytolytic and noncytolytic T cell lines with specificity for minor histocompatibility antigens.对次要组织相容性抗原有特异性的抗原依赖性、H-2限制性细胞毒性和非细胞毒性T细胞系。
Eur J Immunol. 1982 May;12(5):365-73. doi: 10.1002/eji.1830120503.
9
T cell lines with dual specificity for strong Mls and H-2 determinants.对强Mls和H-2决定簇具有双重特异性的T细胞系。
J Immunol. 1980 Dec;125(6):2643-5.
10
Surface markers of T cells causing lethal graft-vs-host disease to class I vs class II H-2 differences.导致致死性移植物抗宿主病的T细胞表面标志物与I类和II类H-2差异。
J Immunol. 1985 Nov;135(5):3004-10.
引用本文的文献
1
Dual genetic regulation by H-2 and non-H-2-linked genes of the magnitude and isotypic pattern of the dinitrophenyl antibody response to DNP-GAT conjugate.H-2和非H-2连锁基因对二硝基苯基抗体针对二硝基苯基-谷氨酸-丙氨酸-酪氨酸（DNP-GAT）偶联物反应的强度和同型模式的双重遗传调控。
Immunogenetics. 1982;15(2):213-20. doi: 10.1007/BF00621953.
2
Leishmania donovani infection in heterozygous and recombinant H-2 haplotype mice.杜氏利什曼原虫在杂合及重组H-2单倍型小鼠中的感染
Immunogenetics. 1983;18(2):101-9. doi: 10.1007/BF00368537.
3
Role of the H-2 complex in induction of T helper cells in vivo. III. Contribution of the I-E subregion to restriction sites recognized by I-A/E-restricted T cells.H-2复合体在体内诱导T辅助细胞中的作用。III. I-E亚区对I-A/E限制性T细胞识别的限制位点的贡献。
J Exp Med. 1982 Feb 1;155(2):548-56. doi: 10.1084/jem.155.2.548.
4
T cell regulation of b cell activation. Cloned Lyt-1+2-T suppressor cells inhibit the major histocompatibility complex-restricted interaction of T helper cells with B cells and/or accessory cells.T细胞对B细胞激活的调节。克隆的Lyt-1+2-T抑制细胞可抑制T辅助细胞与B细胞和/或辅助细胞之间主要组织相容性复合体限制的相互作用。
J Exp Med. 1983 Oct 1;158(4):1178-90. doi: 10.1084/jem.158.4.1178.
5
Fine specificity of a proliferating T-cell clone activated by a conformational determinant of the I-Ek molecule.由I-Ek分子的构象决定簇激活的增殖性T细胞克隆的精细特异性。
Immunogenetics. 1982;15(4):399-412. doi: 10.1007/BF00364263.
6
Inhibition of T cell activation in vivo with mixtures of monoclonal antibodies specific for I-A and I-A/E molecules.使用针对I-A和I-A/E分子的单克隆抗体混合物在体内抑制T细胞活化。
J Exp Med. 1981 Jul 1;154(1):188-92. doi: 10.1084/jem.154.1.188.
7
Immune suppression genes.免疫抑制基因。
Clin Exp Immunol. 1989 Feb;75(2):167-77.
本文引用的文献
1
Features of cells controlling H-2-restricted presentation of antigen to T helper cells in vivo.
J Immunol. 1980 Nov;125(5):2089-96.
2
Gene complementation. Neither Ir-GLphi gene need be present in the proliferative T cell to generate an immune response to Poly(Glu55Lys36Phe9)n.基因互补。在增殖性T细胞中，无需存在任何一个Ir - GLphi基因即可对聚（Glu55Lys36Phe9）n产生免疫反应。
J Exp Med. 1980 Jun 1;151(6):1452-67. doi: 10.1084/jem.151.6.1452.
3
Effects of blocking helper T cell induction in vivo with anti-Ia antibodies. Possible role of I-A/E hybrid molecules as restriction elements.用抗Ia抗体在体内阻断辅助性T细胞诱导的作用。I-A/E杂交分子作为限制元件的可能作用。
J Exp Med. 1980 Oct 1;152(4):996-1010. doi: 10.1084/jem.152.4.996.
4
Antigen-reactive T cell clones. I. Transcomplementing hybrid I-A-region gene products function effectively in antigen presentation.抗原反应性T细胞克隆。I. 转互补杂交I-A区基因产物在抗原呈递中有效发挥作用。
J Exp Med. 1980 Oct 1;152(4):759-70. doi: 10.1084/jem.152.4.759.
5
Monoclonal antibody against an Ir gene product?针对免疫反应基因产物的单克隆抗体？
J Exp Med. 1980 Oct 1;152(4):1085-101. doi: 10.1084/jem.152.4.1085.
6
Control of t-lymphocyte and B-lymphocyte activation by two complementing Ir-GLphi immune response genes.两个互补的Ir-GLphi免疫反应基因对T淋巴细胞和B淋巴细胞激活的控制
J Exp Med. 1976 Apr 1;143(4):906-18. doi: 10.1084/jem.143.4.906.
7
The role of macrophages in the generation of T-helper cells. II. The genetic control of the macrophage-T-cell interaction for helper cell induction with soluble antigens.巨噬细胞在辅助性T细胞生成中的作用。II. 巨噬细胞与T细胞相互作用以通过可溶性抗原诱导辅助性细胞的遗传控制。
J Exp Med. 1975 Aug 1;142(2):460-72. doi: 10.1084/jem.142.2.460.
8
The function and interrelationships of T-cell receptors, Ir genes and other histocompatibility gene products.T细胞受体、免疫反应基因及其他组织相容性基因产物的功能与相互关系。
Transplant Rev. 1975;22:175-95. doi: 10.1111/j.1600-065x.1975.tb01559.x.
9
Role of the H-2 complex in induction of T helper cells in vivo. I. Antigen-specific selection of donor T cells to sheep erythrocytes in irradiated mice dependent upon sharing of H-2 determinants between donor and host.H-2复合体在体内诱导T辅助细胞中的作用。I. 照射小鼠体内供体T细胞对绵羊红细胞的抗原特异性选择取决于供体与宿主之间H-2决定簇的共享。
J Exp Med. 1978 Aug 1;148(2):478-89. doi: 10.1084/jem.148.2.478.
10
Restricted helper function of F1 hybrid T cells positively selected to heterologous erythrocytes in irradiated parental strain mice. II. Evidence for restrictions affecting helper cell induction and T-B collaboration, both mapping to the K-end of the H-2 complex.在经辐照的亲代品系小鼠中对异源红细胞进行阳性选择的F1杂种T细胞的受限辅助功能。II. 影响辅助细胞诱导和T-B协作的限制证据，二者均定位于H-2复合体的K端。
J Exp Med. 1978 Apr 1;147(4):1159-74. doi: 10.1084/jem.147.4.1159.
Zotero 插件