巨噬细胞在辅助性T细胞生成中的作用。II. 巨噬细胞与T细胞相互作用以通过可溶性抗原诱导辅助性细胞的遗传控制。
The role of macrophages in the generation of T-helper cells. II. The genetic control of the macrophage-T-cell interaction for helper cell induction with soluble antigens.
作者信息
Erb P, Feldmann M
出版信息
J Exp Med. 1975 Aug 1;142(2):460-72. doi: 10.1084/jem.142.2.460.
Abstract
Helper cell induction to nonparticle antigens in vitro requires the cooperation of T cells and macrophages, but does not occur if the macrophages are allogenic. The reasons for this were investigated. Malfunction of allogenic macrophages was excluded by cultures with their syngenic T cells; suppressor cell induction was excluded by admixture experiments. Thus, T cells and macrophages only cooperated if they were genetically similar. The genetic locus (loci) involved was mapped. Using congenic lines differing only at the H-2 complex, the genetic control of T-macrophage interaction was localized in the H-2 region. Mice with intra H-2 recombinants were used to map the T-macrophage interaction locus in the I-A region of the H-2 complex (formerly known as poly-D, L-ala-poly-L-lys. Recombinants were also used to exclude the presence of another T-macrophage locus either the K, I-B, or I-C, SS-Slp, or D regions of the H-2 complex. Genetic restrictions for T-macrophage interaction in helper cell induction was shown in mice of the H-2-k, d, b, q, s genotypes as well as in H-2 recombinants. The possible mechanisms and significance of this genetic restriction are discussed.
摘要
体外将辅助性细胞诱导至非颗粒性抗原需要T细胞和巨噬细胞的协同作用，但如果巨噬细胞是同种异体的则不会发生这种情况。对此原因进行了研究。通过与其同基因T细胞共培养排除了同种异体巨噬细胞的功能异常；通过混合实验排除了抑制性细胞的诱导。因此，只有当T细胞和巨噬细胞基因相似时它们才会协同作用。对涉及的遗传位点进行了定位。利用仅在H-2复合体上存在差异的同类系，将T细胞-巨噬细胞相互作用的遗传控制定位在H-2区域。使用具有H-2复合体内重组体的小鼠将T细胞-巨噬细胞相互作用位点定位在H-2复合体的I-A区域（以前称为聚-D，L-丙氨酸-聚-L-赖氨酸。重组体也用于排除H-2复合体的K、I-B、I-C、SS-Slp或D区域中另一个T细胞-巨噬细胞位点的存在。在H-2-k、d、b、q、s基因型的小鼠以及H-2重组体中均显示了辅助性细胞诱导中T细胞-巨噬细胞相互作用的遗传限制。讨论了这种遗传限制的可能机制和意义。
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