Institute of Clinical Pharmacology, OE 5350, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625, Germany.
Drugs. 2013 Aug;73(12):1267-79. doi: 10.1007/s40265-013-0097-0.
The maintenance of blood pressure in the upright position requires intact autonomic cardiovascular reflexes. Diseases that affect the sympathetic innervation of the cardiovascular system result in a sustained fall in blood pressure upon standing (i.e., neurogenic orthostatic hypotension) that can impair the blood supply to the brain and other organs and cause considerable morbidity and mortality. Here we review treatment options for neurogenic orthostatic hypotension and include an algorithm for its management that emphasizes the importance of non-pharmacologic measures and provides guidance on pharmacologic treatment options.
在直立位时维持血压需要完整的自主心血管反射。影响心血管系统交感神经支配的疾病会导致站立时血压持续下降（即神经源性直立性低血压），从而损害大脑和其他器官的血液供应，并导致相当大的发病率和死亡率。在这里，我们回顾了神经源性直立性低血压的治疗选择，并包括了其管理的算法，强调了非药物治疗措施的重要性，并提供了药物治疗选择的指导。
