Hösli L, Hösli E, Zehntner C, Landolt H
Neurosci Lett. 1981 Jul 2;24(2):165-8. doi: 10.1016/0304-3940(81)90242-1.
Substance P caused a depolarization of cultured spinal neurones which was often accompanied by a decrease in membrane conductance. The peptide usually had no effect on the membrane potential and resistance of glial cells. In contrast to the depolarization by glutamate, which is associated with an influx of Na+ and an efflux of K+, the action of substance P may be due to a decrease of the K+-conductance.
P物质可使培养的脊髓神经元去极化，这种去极化常伴有膜电导降低。该肽通常对神经胶质细胞的膜电位和电阻无影响。与谷氨酸引起的去极化不同，谷氨酸引起的去极化与Na⁺内流和K⁺外流有关，P物质的作用可能是由于K⁺电导降低所致。
