由谷氨酸盐和天冬氨酸盐激发的神经元释放钾离子会导致培养的神经胶质细胞去极化。
Efflux of potassium from neurones excited by glutamate and aspartate causes a depolarization of cultured glial cells.
作者信息
Hösli L, Hösli E, Landolt H, Zehntner C
出版信息
Neurosci Lett. 1981 Jan 1;21(1):83-6. doi: 10.1016/0304-3940(81)90062-8.
PMID:7207872
Abstract
The time course of the depolarization of cultured astrocytes and neurones by glutamate and aspartate corresponds well with the increase of the extracellular K+ concentration ([K +]0) measured with an ion-sensitive microelectrode placed in the close vicinity of the cells tested. It is concluded that the depolarization of glial cells is caused by an efflux of K+ from neighbouring neurones during their excitation by the amino acids.
摘要
谷氨酸和天冬氨酸使培养的星形胶质细胞和神经元去极化的时间进程，与用置于受试细胞附近的离子敏感微电极测得的细胞外钾离子浓度（[K +]0）的增加非常吻合。得出的结论是，在氨基酸激发相邻神经元的过程中，钾离子从这些神经元外流导致了神经胶质细胞的去极化。
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