Lobacheva I I, Popova N K
Ontogenez. 1981;12(3):306-10.
The content of serotonin and 5-hydroxy-indole-acetic acid (5-HIAA) was determined in the brain stem and hemispheres in 1 and 3 months old C57BL/6J and BALB/cLac mice. The characteristic dynamics of serotonin and its metabolite content related to the age was found in different brain regions and proved to be similar in both the strains, but the rate of serotonin system development in C57BL/6J mice was higher than in BALB/c Lac mice. An intensive catabolism of serotonin, possibly, related to the reaction to new environment was noted in the newborn animals. Sex differences in the rate of serotonin system maturation and serotonin and 5-HIAA content were shown for 12--16 days old mice: 12 days old males were characterized by more intensive metabolism than females while 16 days old males had less serotonin than females.
测定了1月龄和3月龄C57BL/6J及BALB/cLac小鼠脑干和大脑半球中血清素和5-羟基吲哚乙酸（5-HIAA）的含量。在不同脑区发现了血清素及其代谢产物含量与年龄相关的特征性动态变化，且在两个品系中均相似，但C57BL/6J小鼠血清素系统的发育速度高于BALB/c Lac小鼠。新生动物中血清素的分解代谢增强，这可能与对新环境的反应有关。研究显示了12至16日龄小鼠血清素系统成熟速率以及血清素和5-HIAA含量的性别差异：12日龄雄性小鼠的代谢比雌性更活跃，而16日龄雄性小鼠的血清素含量低于雌性。
