Common antigenic sites in human, bovine and porcine fibrinogens.

Specific antisera to the A alpha, B beta and gamma chains of porcine fibrinogen were used to characterize an antigenic homology of human, bovine, and porcine fibrinogens. Antigenic determinants shared by these fibrinogens were mostly formed by the A alpha chain. However, in the case of bovine and porcine fibrinogens they were also found in the B beta and gamma polypeptide chains. The results reported here show that the A alpha chain determinants exposed on the intact fibrinogen molecule are conserved to a considerably larger extent than those of the B beta and gamma chains.