Whipple's disease, successful response to sulfamethoxazole-trimethoprim.

Because of allergy to penicillin and intolerance to tetracycline, a 47-year old man, known to have Whipple's disease, was treated with sulfamethoxazole-trimethoprim, one tablet two times a day for six months. The patient has remained in remission one year after medication was discontinued. Sulfamethoxazole-trimethoprim may be the treatment of choice for Whipple's disease.