Nizet A
Arch Int Physiol Biochim. 1980 Dec;88(5):505-9. doi: 10.3109/13813458009092926.
Sodium excretion, renal blood flow and glomerular filtration rate were investigated in isolated, blood-perfused dog kidneys, thus excluding the interference of changes in body sodium and water balance. Four groups of experiments were performed : (a) control; (b) blood + indomethacin; (c) blood + furosemide; (d) blood + furosemide and indomethacin. The progressive vasodilatation due to the accumulation of prostaglandins was suppressed by indomethacin, the glomerular filtration rate remaining unchanged. The inhibition of prostaglandins synthesis was without influence on the natriuretic activity of furosemide. These results seem incompatible with an intrarenal mediation by prostaglandins of the diuretic effect of furosemide; moreover, this effect was dissociated from the changes in renal blood flow ascribed to renal prostaglandins.
在离体、血液灌注的犬肾中研究了钠排泄、肾血流量和肾小球滤过率，从而排除了机体钠和水平衡变化的干扰。进行了四组实验：(a)对照组；(b)血液+吲哚美辛；(c)血液+呋塞米；(d)血液+呋塞米和吲哚美辛。吲哚美辛抑制了因前列腺素蓄积所致的渐进性血管舒张，而肾小球滤过率保持不变。前列腺素合成的抑制对呋塞米的利钠活性没有影响。这些结果似乎与前列腺素在肾内介导呋塞米的利尿作用不相容；此外，这种作用与归因于肾前列腺素的肾血流量变化无关。
