Feigen L P, Klainer E, Chapnick B M, Kadowitz P J
J Pharmacol Exp Ther. 1976 Aug;198(2):457-63.
The effects of indomethacin, an inhibitor of prostaglandin synthesis, on renal blood flow, glomerular filtration rate, urine flow and excretion of sodium and potassium were studied in the anesthetized dog. Indomethacin, 2.5 mg/kg i.v., decreased renal blood flow but increased aortic pressure and calculated renal vascular resistance. Glomerular filtration rate was not influenced by the synthetase inhibitor. Sodium excretion was decreased and para-aminohippurate extraction was increased after administration of indomethacin. Transient decreases in urine flow and potassium excretion were observed; however, both parameters returned to control value 75 minutes after administration of indomethacin. The early decrease in urine flow rate correlated closely with the decrease in sodium excretion. These data suggest that in the anesthetized dog, endogenous prostaglandins may serve to maintain renal blood flow but not glomerular filtration rate. Under the conditions of the present experiments, sodium excretion and to a lesser extent potassium excretion have been suggested as being dependent on prostaglandin synthesis.
在麻醉犬身上研究了前列腺素合成抑制剂吲哚美辛对肾血流量、肾小球滤过率、尿流量以及钠和钾排泄的影响。静脉注射2.5毫克/千克的吲哚美辛可降低肾血流量，但会升高主动脉血压并增加计算得出的肾血管阻力。肾小球滤过率不受该合成酶抑制剂的影响。给药后，钠排泄减少，对氨基马尿酸提取增加。观察到尿流量和钾排泄出现短暂下降；然而，在给予吲哚美辛75分钟后，这两个参数均恢复到对照值。尿流率的早期下降与钠排泄的减少密切相关。这些数据表明，在麻醉犬中，内源性前列腺素可能有助于维持肾血流量，但对肾小球滤过率无作用。在本实验条件下，钠排泄以及在较小程度上钾排泄被认为依赖于前列腺素合成。
