Radius R L
Arch Ophthalmol. 1981 Jul;99(7):1253-7. doi: 10.1001/archopht.1981.03930020127016.
The distribution of transport abnormalities in primate optic nerve from eyes subjected to five hours of pressure elevation (perfusion pressure of 35 mm Hg) was studied. Tissue autoradiography and electron microscopy were used to localize regions of the lamina cribrosa with increased transport interruption. A preferential involvement by this transport abnormality involved the superior, temporal, and inferior portions, to the exclusion of the nasal portion, of the optic nerve head. This observation supports the hypothesis that transport interruption seen in this model may be pertinent to the study of clinical glaucomatous neuropathy.
研究了灵长类动物视神经在眼压升高5小时（灌注压35毫米汞柱）后的转运异常分布情况。采用组织放射自显影术和电子显微镜来定位筛板中转运中断增加的区域。这种转运异常优先累及视神经乳头的上半部分、颞侧部分和下半部分，而鼻侧部分未受影响。这一观察结果支持了这样一种假设，即该模型中所见的转运中断可能与临床青光眼性神经病变的研究相关。
