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本文引用的文献

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Hypothesis concerning the pathophysiology of optic nerve damage in open angle glaucoma.关于开角型青光眼视神经损伤病理生理学的假说。
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Adaptive optics scanning laser ophthalmoscopy.自适应光学扫描激光检眼镜
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Direct and noninvasive assessment of parafoveal capillary leukocyte velocity.黄斑旁毛细血管白细胞速度的直接和非侵入性评估。
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Factors influencing optic nerve head biomechanics.影响视神经乳头生物力学的因素。
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Dynamic visual stimulus presentation in an adaptive optics scanning laser ophthalmoscope.自适应光学扫描激光检眼镜中的动态视觉刺激呈现
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Optical slicing of human retinal tissue in vivo with the adaptive optics scanning laser ophthalmoscope.使用自适应光学扫描激光检眼镜对人视网膜组织进行体内光学切片。
Appl Opt. 2005 Jul 1;44(19):4032-40. doi: 10.1364/ao.44.004032.
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Viscoelastic material properties of the peripapillary sclera in normal and early-glaucoma monkey eyes.正常和早期青光眼猴眼视乳头周围巩膜的粘弹性材料特性
Invest Ophthalmol Vis Sci. 2005 Feb;46(2):540-6. doi: 10.1167/iovs.04-0114.
8
The optic nerve head as a biomechanical structure: a new paradigm for understanding the role of IOP-related stress and strain in the pathophysiology of glaucomatous optic nerve head damage.作为生物力学结构的视神经乳头：理解眼内压相关应力和应变在青光眼性视神经乳头损害病理生理学中作用的新范式。
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Three dimensional analysis of the lamina cribrosa in glaucoma.青光眼筛板的三维分析
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10
Efficacy and safety of memantine treatment for reduction of changes associated with experimental glaucoma in monkey, II: Structural measures.美金刚治疗对减轻猴实验性青光眼相关变化的疗效和安全性，II：结构测量
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用于筛板体内成像的自适应光学扫描激光检眼镜

Adaptive optics scanning laser ophthalmoscopy for in vivo imaging of lamina cribrosa.

作者信息

Vilupuru Abhiram S, Rangaswamy Nalini V, Frishman Laura J, Smith Earl L, Harwerth Ronald S, Roorda Austin

机构信息

College of Optometry, University of Houston, TX 77204-2020, USA.

出版信息

J Opt Soc Am A Opt Image Sci Vis. 2007 May;24(5):1417-25. doi: 10.1364/josaa.24.001417.

DOI:10.1364/josaa.24.001417
PMID:17429488
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4696388/
Abstract

The lamina cribrosa has been postulated from in vitro studies as an early site of damage in glaucoma. Prior in vivo measures of laminar morphology have been confounded by ocular aberrations. In this study the lamina cribrosa was imaged after correcting for ocular aberrations using the adaptive optics scanning laser ophthalmoscope (AOSLO) in normal and glaucomatous eyes of rhesus monkeys. All measured laminar morphological parameters showed increased magnitudes in glaucomatous eyes relative to fellow control eyes, indicating altered structure. The AOSLO provides high-quality images of the lamina cribrosa and may have potential as a tool for early identification of glaucoma.

摘要

从体外研究推测，筛板是青光眼早期损伤的部位。先前对板层形态的体内测量因眼像差而受到干扰。在本研究中，使用自适应光学扫描激光检眼镜（AOSLO）校正眼像差后，对恒河猴正常眼和青光眼眼中的筛板进行成像。所有测量的板层形态学参数显示，青光眼眼相对于对侧对照眼的数值增加，表明结构发生了改变。AOSLO能提供高质量的筛板图像，可能具有作为早期青光眼识别工具的潜力。