Willenborg D O, Higgins T J
Aust J Exp Biol Med Sci. 1981 Apr;59(Pt 2):135-41. doi: 10.1038/icb.1981.9.
The ability of rats to respond immunologically to myelin basic protein (BP) incorporated into liposomes was tested. BP-liposomes administered intradermally or intravenously to naive rats were non-encephalitogenic, did not induce antibody or cellular reactivity to BP, nor did they protect against a subsequent challenge with BP in complete Freund's adjuvant (CFA). Intravenous administration of BP-liposomes to sensitized rats, however, suppressed EAE if given shortly before the expected onset of clinical signs. The same dose of BP in saline fails to suppress the appearance of clinical experimental allergic encephalomyelitis (EAE).
对大鼠对掺入脂质体的髓鞘碱性蛋白（BP）产生免疫反应的能力进行了测试。将BP-脂质体皮内或静脉内给予未致敏的大鼠时，它们不具有致脑炎性，不会诱导对BP的抗体或细胞反应性，也不能预防随后用完全弗氏佐剂（CFA）中的BP进行的攻击。然而，如果在预期临床症状出现前不久静脉内给予致敏大鼠BP-脂质体，则可抑制实验性自身免疫性脑脊髓炎（EAE）。相同剂量的BP溶于盐水中则无法抑制临床实验性变应性脑脊髓炎（EAE）的出现。
