Truneh A, Pearce F L
Int Arch Allergy Appl Immunol. 1981;66(1):76-82. doi: 10.1159/000232802.
The anti-allergic drugs theophylline, doxantrazole, quercetin, dibutyryl cyclic AMP, and disodium cromoglycate prevented histamine release induced by concanavalin A in both the presence and absence of extracellular calcium. The compounds were generally most effective in the absence of added calcium and least effective in the simultaneous presence of calcium and phosphatidyl serine. The activity of the test drugs in calcium-free media clearly cannot be explained in terms of their postulated ability to block movement of the ion from the external environment into the cell. Alternative modes of action are thus considered.
抗组胺药物茶碱、多沙唑嗪、槲皮素、二丁酰环磷腺苷和色甘酸钠在细胞外钙存在和不存在的情况下，均能阻止伴刀豆球蛋白A诱导的组胺释放。这些化合物通常在不添加钙的情况下效果最佳，而在钙和磷脂酰丝氨酸同时存在时效果最差。显然，受试药物在无钙培养基中的活性不能用它们假定的阻止离子从外部环境进入细胞的能力来解释。因此，考虑了其他作用方式。
