抗过敏化合物在有和没有外源性钙存在的情况下对大鼠腹膜肥大细胞过敏组胺分泌的影响。
Effect of anti-allergic compounds on anaphylactic histamine secretion from rat peritoneal mast cells in the presence and absence of exogenous calcium.
作者信息
White J R, Pearce F L
出版信息
Immunology. 1982 Jun;46(2):361-7.
Abstract
The anti-allergic drugs theophylline, doxantrazole, quercetin, 8-bromo cyclic AMP, and disodium cromoglycate prevented anaphylactic histamine release from rat peritoneal mast cells in both the presence and absence of extracellular calcium. The activity of the test compounds under the latter conditions cannot be simply explained in terms of their postulated ability to block movement of the cation from the external environment into the cell. Alternative modes of action are thus considered.
摘要
抗组胺药物茶碱、多沙唑嗪、槲皮素、8-溴环磷酸腺苷和色甘酸钠在细胞外钙存在和不存在的情况下，均能阻止大鼠腹膜肥大细胞释放过敏组胺。在后一种情况下，受试化合物的活性不能简单地用它们假定的阻止阳离子从外部环境进入细胞的能力来解释。因此考虑了其他作用方式。
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