Parham P, McLean J
Hum Immunol. 1980 Sep;1(2):131-9. doi: 10.1016/0198-8859(80)90100-7.
In our search for monoclonal antibodies defining specific HLA-A,B antigens we have found a significant number of antibodies with polymorphic reactions that are not explicable with our current picture of HLA-A,B interrelationships. Analysis of one antibody (MB40.1) in some detail shows that it recognizes subsets of both A and B antigens and that it is able to split highly cross-reactive pairs of A or B antigens. These results address an outstanding difference in the serological interpretation of H-2, where these types of public reactions have been well established, from HLA, where they have been poorly characterized. Comparison of these types of serological reactions with amino acid sequence data and the apparent evolutionary stability of these broad cross-reacting determinants suggests a simple model for the molecular nature based upon limited amino acid variability and convergent evolution.
在我们寻找定义特定HLA - A、B抗原的单克隆抗体的过程中，我们发现了大量具有多态反应的抗体，这些反应无法用我们目前对HLA - A、B相互关系的认识来解释。对一种抗体（MB40.1）的详细分析表明，它能识别A和B抗原的亚群，并且能够区分高度交叉反应的A或B抗原对。这些结果揭示了H - 2血清学解释中一个显著的差异，在H - 2中这类公共反应已得到充分证实，而在HLA中这类反应的特征却很不明确。将这些血清学反应类型与氨基酸序列数据以及这些广泛交叉反应决定簇明显的进化稳定性进行比较，提示了一个基于有限氨基酸变异性和趋同进化的分子性质简单模型。
