Alloantigens of the human T (HT) genetic region of the HLA linkage group.

This article describes an approach that characterizes alloantisera reactive with new determinants on mitogen-activated human lymphocytes. These markers, which are tentatively called HT-antigens, are different from the classical HLA-A,C,C, and DR antigens but are associated with beta 2-microglobulin. Several alloantisera were tested extensively on lymphocytes that were treated initially with an antigen-blocking technique using turkey anti-beta 2-microglobulin and turkey anti-p29,34 sera or with an antigen-modulation technique using xeno- and alloantisera. It was concluded that these tested antisera recognized three different determinants (HT1, HT3, and HT (1 + 3) that appeared to segregate with the HLA-A locus of the HLA haplotype. HT antigens may be analogous to the murine TL-Qa antigens since HT antigens are associated with beta 2-microglobulin, are generally related to the HLA region, and are expressed on mitogen activated T cells but not on resting T cells.