一个HLA基因的外显子/内含子结构及完整核苷酸序列
Exon/intron organization and complete nucleotide sequence of an HLA gene.
作者信息
Malissen M, Malissen B, Jordan B R
出版信息
Proc Natl Acad Sci U S A. 1982 Feb;79(3):893-7. doi: 10.1073/pnas.79.3.893.
Abstract
We have isolated and determined the sequence of a genomic clone containing the gene for a human class I transplantation antigen. The gene contains seven exons. The first five exons code respectively for a signal peptide, for the first, second, and third extracellular domains of the protein molecule, and for the transmembrane region. The cytoplasmic segment is encoded by part of the fifth and the sixth and the seventh exons. The structure of the protein encoded by this unit is closely homologous with known class I transplantation antigens.
摘要
我们已经分离并确定了一个包含人类I类移植抗原基因的基因组克隆的序列。该基因包含七个外显子。前五个外显子分别编码一个信号肽、蛋白质分子的第一、第二和第三细胞外结构域以及跨膜区域。细胞质区段由第五、第六和第七外显子的一部分编码。该单元编码的蛋白质结构与已知的I类移植抗原密切同源。
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