Arya S K, Gordon B
J Gen Virol. 1981 Apr;53(Pt 2):383-7. doi: 10.1099/0022-1317-53-2-383.
The sensitivity of mouse mammary tumour virus (MMTV) and murine leukaemia virus (MuLV) to interferon was tested by investigating the effect of interferon in cultures of mouse mammary tumour cells simultaneously synthesizing the two viruses. The dose-response curves showed that the extracellular production of both viruses by these cells was equally inhibited by interferon treatment. In contrast, the intracellular steady-state concentration of virus-specific RNA of both MMTV and MuLV was not significantly affected in these cells. This was the case regardless of whether total cellular RNA or polysomal poly(A)-containing RNA was examined. These results are consistent with the suggestion that interferon-caused inhibition is related to a host-mediated effect on a post-transcriptional step in virus synthesis.
通过研究干扰素对同时合成小鼠乳腺肿瘤病毒（MMTV）和鼠白血病病毒（MuLV）的小鼠乳腺肿瘤细胞培养物的影响，测试了这两种病毒对干扰素的敏感性。剂量反应曲线表明，这些细胞产生的两种病毒的细胞外产量均受到干扰素处理的同等抑制。相比之下，MMTV和MuLV的病毒特异性RNA在这些细胞中的细胞内稳态浓度并未受到显著影响。无论检测的是总细胞RNA还是多核糖体含聚腺苷酸（poly(A)）的RNA，都是如此。这些结果与以下观点一致，即干扰素引起的抑制与宿主介导的对病毒合成转录后步骤的影响有关。
