Schröder M, von Heyden H W, Beyer J H, Klee M
Laryngol Rhinol Otol (Stuttg). 1981 Jun;60(6):331-3.
Treatment of patients with advanced squamous head and neck tumors demonstrates even with best surgical and x-ray techniques only five year survival rats between 10 and 30%. Chemotherapy in addition seems to improve these results. From July 79 to January 80 21 patients with advanced squamous-cell carcinoma at the head and neck region were treated in a controlled pilot study with Cisplatinum/Bleomycin or Methotrexate/vindesine. 6 patients were primarily treated with chemotherapy, all other secondary progressive disease after surgical and x-ray procedure. Without respect to the generally cell tolerated therapy modality on overall remission induction rate of 50 and 70% was observed. In a subsequent randomized controlled multicentric study both regimes will be compared concerning remission, survival and toxicity.
对晚期鳞状头颈肿瘤患者的治疗表明，即便采用最佳的手术和X光技术，五年生存率也仅在10%至30%之间。此外，化疗似乎能改善这些结果。从1979年7月至1980年1月，在一项对照性初步研究中，用顺铂/博来霉素或甲氨蝶呤/长春地辛对21例晚期头颈区域鳞状细胞癌患者进行了治疗。6例患者首先接受化疗，其他所有患者在手术和X光治疗后出现继发性进展性疾病。无论采用何种一般细胞耐受的治疗方式，总体缓解诱导率均观察到为50%和70%。在随后的一项随机对照多中心研究中，将对这两种治疗方案在缓解、生存和毒性方面进行比较。
