Roxe D M, Siddiqui F, Santhanam S, del Greco F, Wolf J
Nephron. 1981;27(4-5):260-4. doi: 10.1159/000182064.
Serum and urinary concentrations of beta 2-microglobulin were measured for the first 21 days after renal transplantation to aid in diagnosis of acute rejection. Criteria developed after study of 15 patients were applied to the entire group of 31 consecutive cases. 29 instances meeting our criteria were identified in 651 days at risk and were associated with a mean maximal increase of serum creatinine of 74.8%. beta 2-Microglobulin methods may make possible detection of what is now subclinical rejection. beta 2-Microglobulin methods, however, are an adjunct to, not a replacement for classical methods for detecting acute rejection.
在肾移植后的前21天测量血清和尿液中β2-微球蛋白的浓度，以辅助急性排斥反应的诊断。对15例患者进行研究后制定的标准应用于连续31例的整个研究组。在651天的观察期内，共识别出29例符合我们标准的病例，这些病例与血清肌酐平均最大增幅74.8%相关。β2-微球蛋白检测方法可能使目前亚临床排斥反应的检测成为可能。然而，β2-微球蛋白检测方法只是检测急性排斥反应的经典方法的辅助手段，而非替代方法。
