Vincent C, Revillard J P
Pathol Biol (Paris). 1978 Sep;26(6):307-11.
beta2-Microglobulin (beta2m)levels were measured daily after transplantation in 44 recipients of renal allograft. beta2m was measured by radioimmunoassay. After transplantation, serum beta2m becomes inferior to 4 micrograms/ml within 4 days whereas urinary beta2m decreases down to 0,5 microgram/ml within 6 days. A correlation between serum creatinine and serumbeta2m is presented and a few dissociations between the 2 values are discussed. Picks of urinary beta2m concentrations were observed either before (22/30 cases) or concomitant (16/30 cases) with rejection episodes. However, a few patients presented massive urinary excretion of beta2m without development of a typical rejection. This study allows to define two types of renal alterations after transplantation : one associated with renal insufficiency and elevated serum beta2m, the other with proximal tubular dysfonction resulting in massive (up to 700 mg/24 h) urinary excretion of beta2m.
对44例同种异体肾移植受者在移植后每日测量β2微球蛋白（β2m）水平。β2m采用放射免疫测定法测量。移植后，血清β2m在4天内降至4微克/毫升以下，而尿β2m在6天内降至0.5微克/毫升以下。给出了血清肌酐与血清β2m之间的相关性，并讨论了这两个值之间的一些分离情况。在排斥反应发作之前（22/30例）或同时（16/30例）观察到尿β2m浓度峰值。然而，一些患者出现β2m大量尿排泄，但未发生典型排斥反应。本研究有助于定义移植后两种类型的肾脏改变：一种与肾功能不全和血清β2m升高有关，另一种与近端肾小管功能障碍有关，导致β2m大量（高达700毫克/24小时）尿排泄。
