慢性乙型肝炎病毒诱导的肝病的免疫发病机制。
The immunopathogenesis of chronic HBV induced liver disease.
作者信息
Levy G A, Chisari F V
出版信息
Springer Semin Immunopathol. 1981 Apr;3(4):439-59. doi: 10.1007/BF01951492.
Abstract
In conclusion, until the cellular biology of hepatitis B virus infection is understood and until the technology for the development of suitable virus infected autologous target cells is available, it will not be possible to definitively establish the mechanism involved in the pathogenesis of hepatitis B virus induced hepatocellular injury. Clearly, considerable effort must now be focused on the basic biology of virus infection, replication, and effects on hepatocellular metabolism before it will be possible to perform the definitive experiments to elucidate the role played by the immune system in the pathogenesis of this disease.
摘要
总之，在了解乙型肝炎病毒感染的细胞生物学以及开发合适的病毒感染自体靶细胞的技术可用之前，不可能明确确定乙型肝炎病毒诱导肝细胞损伤发病机制中所涉及的机制。显然，在能够进行明确的实验以阐明免疫系统在该疾病发病机制中所起的作用之前，现在必须将大量精力集中在病毒感染、复制及其对肝细胞代谢影响的基础生物学研究上。
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