Chisari F V, Bieber M S, Josepho C A, Xavier C, Anderson D S
J Immunol. 1981 Jan;126(1):45-9.
Cytotoxic effector cell responsiveness to host and/or virus-determined hepatocyte surface membrane antigens has been postulated as an important pathogenetic determinant of hepatocellular injury in hepatitis B virus infection. Assuming that such effector cell populations would be detectable in peripheral blood, the present study was designed to examine 2 questions: first, whether target cells that normally express liver-specific protein (LSP) and hepatitis B surface antigen (HBsAg) are selectively destroyed by peripheral blood effector cells from patients with viral hepatitis; second, whether cytotoxic effector cell function emerges coincident with the development of defective suppressor cell activity in the same patients. No evidence of increased HBsAg or LSP specific cytotoxic effector cell activity was found in the peripheral blood natural killer (NK) or T killer cell populations of patients with acute or chronic viral hepatitis.
细胞毒性效应细胞对宿主和/或病毒决定的肝细胞表面膜抗原的反应性，被认为是乙型肝炎病毒感染中肝细胞损伤的一个重要发病机制决定因素。假设在外周血中可检测到此类效应细胞群体，本研究旨在探讨两个问题：第一，正常表达肝特异性蛋白（LSP）和乙型肝炎表面抗原（HBsAg）的靶细胞是否被病毒性肝炎患者的外周血效应细胞选择性破坏；第二，在同一患者中，细胞毒性效应细胞功能是否与抑制细胞活性缺陷的发展同时出现。在急性或慢性病毒性肝炎患者的外周血自然杀伤（NK）或T杀伤细胞群体中，未发现HBsAg或LSP特异性细胞毒性效应细胞活性增加的证据。
