Lahaie R G, Dagorn J C
Biochim Biophys Acta. 1981 Jun 26;654(1):119-23. doi: 10.1016/0005-2787(81)90143-x.
The kinetics of the adaptative changes in the relative rates of synthesis and pancreatic concentrations of amylase, chymotrypsinogen and trypsinogen were studied over 10 days of adaptation to a carbohydrate-rich (G), or a protein-rich (P) diet. During adaptation to the P diet, 60% of the adaptative decrease of the amylase to chymotrypsinogen ratio of incorporation was complete within 24 h of feeding and plateau values were obtained after five days. Adaptation to the G diet was only 20% complete after 24 h and plateau values were obtained later than with the P diet. The evolution of the ratio of concentrations of amylase and chymotrypsinogen followed those of incorporation in the adaptation to both diets. These results support the determinant role of adaptative changes in the rates of synthesis of individual enzymes on the dietary adaptation of enzyme proportions in the pancreas. The differences in the kinetics of adaptation to the two diets suggest that different mechanisms are involved in the adaptative regulation of protein synthesis to a carbohydrate-rich diet or a protein-rich diet.
在适应富含碳水化合物（G）或富含蛋白质（P）饮食的10天时间里，研究了淀粉酶、胰凝乳蛋白酶原和胰蛋白酶原的合成相对速率以及胰腺浓度的适应性变化动力学。在适应P饮食期间，淀粉酶与胰凝乳蛋白酶原掺入比率适应性下降的60%在喂食后24小时内完成，五天后达到平稳值。适应G饮食在24小时后仅完成20%，且平稳值比适应P饮食时出现得晚。在适应两种饮食的过程中，淀粉酶和胰凝乳蛋白酶原浓度的比率变化与掺入比率的变化一致。这些结果支持了个体酶合成速率的适应性变化在胰腺中酶比例的饮食适应性方面的决定性作用。适应两种饮食的动力学差异表明，在对富含碳水化合物饮食或富含蛋白质饮食的蛋白质合成适应性调节中涉及不同的机制。
