Menniti F S, Erskine M S, Baum M J
Brain Res Bull. 1981 Jul;7(1):1-4. doi: 10.1016/0361-9230(81)90090-3.
Administering increasing dosages of 5alpha-dihydrotestosterone propionate (DHTP) (0, 40, or 80 microgram/100 g in oil daily) to ovariectomized female rats treated concurrently with estradiol benzoate (EB) (1 microgram/100 g in oil daily) caused significant, equivalent reduction in lordotic responsiveness in rats maintained either on a tryptophan-deficient corn diet or on a corn diet to which L-tryptophan was added. Whole brain concentrations of 5-hydroxytryptamine (5-HT) and of 5-hydroxyindoleacetic acid were approximately two times higher in rats fed corn+tryptophan versus corn alone. These findings suggest that the ability of DHTP to inhibit lordosis probably depends upon some mechanism other than a facilitation of 5HT release from serotonergic neurons.
给同时接受苯甲酸雌二醇（EB）（每天1微克/100克溶于油中）治疗的去卵巢雌性大鼠每日注射递增剂量的丙酸5α-双氢睾酮（DHTP）（0、40或80微克/100克溶于油中），结果发现，无论是维持在缺乏色氨酸的玉米饮食还是添加了L-色氨酸的玉米饮食上的大鼠，其脊柱前凸反应性均显著且同等程度地降低。与单纯喂食玉米的大鼠相比，喂食玉米+色氨酸的大鼠全脑5-羟色胺（5-HT）和5-羟吲哚乙酸的浓度大约高出两倍。这些发现表明，DHTP抑制脊柱前凸的能力可能取决于某种机制，而非促进5HT从5-羟色胺能神经元释放。
