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用雌二醇和双氢睾酮联合治疗后阉割雄性大鼠的交配行为。

Copulation in castrated male rats following combined treatment with estradiol and dihydrotestosterone.

作者信息

Baum M J, Vreeburg J T

出版信息

Science. 1973 Oct 19;182(4109):283-5. doi: 10.1126/science.182.4109.283.

DOI:10.1126/science.182.4109.283
PMID:4742734
Abstract

Castrated male rats injected daily with 2 micrograms of estradiol benzoate (EB) combined with 200 micrograms of dihydrotestosterone propionate (DHTP) displayed masculine mating behavior which was indistinguishable from that of other castrates treated with 200 micrograms of testosterone propionate (TP). Significantly less copulation was seen in rats treated with either 4 micrograms of TP plus 200 micrograms of DHTP or 2 micrograms of EB. Mating in male rats may depend on the action of both estrogenic and 5alpha-dihydro metabolites of testosterone.

摘要

每天注射2微克苯甲酸雌二醇（EB）与200微克丙酸双氢睾酮（DHTP）的去势雄鼠表现出与其他接受200微克丙酸睾酮（TP）治疗的去势鼠无法区分的雄性交配行为。用4微克TP加200微克DHTP或2微克EB治疗的大鼠交配明显减少。雄性大鼠的交配可能取决于睾酮的雌激素和5α-二氢代谢产物的作用。

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