在几种磷酸二酯酶抑制剂存在的情况下，乙酰胆碱的负性肌力作用。
A negative inotropic effect of acetylcholine in the presence of several phosphodiesterase inhibitors.
作者信息
Nawrath H, Gruschwitz P, Zong X
出版信息
Experientia. 1981 Jul 15;37(7):755-6. doi: 10.1007/BF01967963.
PMID:6168488
Abstract
The phosphodiesterase inhibitors papaverine, theophylline and 3-isobutyl-1-methylxanthine (IBMX) reveal a negative inotropic effect of acetylcholine in cat ventricular heart muscle. This effect in unrelated to beta-adrenoceptor stimulation and possibly mediated by the accumulation of cyclic GMP.
摘要
磷酸二酯酶抑制剂罂粟碱、茶碱和3-异丁基-1-甲基黄嘌呤（IBMX）可揭示乙酰胆碱对猫心室肌的负性肌力作用。该作用与β-肾上腺素能受体刺激无关，可能由环鸟苷酸的蓄积介导。
Zotero 插件