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在几种磷酸二酯酶抑制剂存在的情况下，乙酰胆碱的负性肌力作用。

A negative inotropic effect of acetylcholine in the presence of several phosphodiesterase inhibitors.

作者信息

Nawrath H, Gruschwitz P, Zong X

出版信息

Experientia. 1981 Jul 15;37(7):755-6. doi: 10.1007/BF01967963.

DOI:10.1007/BF01967963
PMID:6168488
Abstract

The phosphodiesterase inhibitors papaverine, theophylline and 3-isobutyl-1-methylxanthine (IBMX) reveal a negative inotropic effect of acetylcholine in cat ventricular heart muscle. This effect in unrelated to beta-adrenoceptor stimulation and possibly mediated by the accumulation of cyclic GMP.

摘要

磷酸二酯酶抑制剂罂粟碱、茶碱和3-异丁基-1-甲基黄嘌呤（IBMX）可揭示乙酰胆碱对猫心室肌的负性肌力作用。该作用与β-肾上腺素能受体刺激无关，可能由环鸟苷酸的蓄积介导。

相似文献

1
A negative inotropic effect of acetylcholine in the presence of several phosphodiesterase inhibitors.在几种磷酸二酯酶抑制剂存在的情况下，乙酰胆碱的负性肌力作用。
Experientia. 1981 Jul 15;37(7):755-6. doi: 10.1007/BF01967963.
2
Interaction of phosphodiesterase inhibitors triamterene, papaverine, theophylline, IBMX and amrinone with other positive inotropic acting substances on isolated guinea-pig atria.磷酸二酯酶抑制剂氨苯蝶啶、罂粟碱、茶碱、异丁基甲基黄嘌呤和氨力农与其他正性肌力作用物质对离体豚鼠心房的相互作用。
Arch Int Pharmacodyn Ther. 1987 Jun;287(2):248-57.
3
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5
Effects of the triazolopyrimidine trapidil on force of contraction, beating frequency and phosphodiesterase I--IV activity in guinea-pig hearts.三唑并嘧啶类药物曲匹地尔对豚鼠心脏收缩力、搏动频率及磷酸二酯酶I-IV活性的影响。
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引用本文的文献

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Antimuscarinic action of quinidine on the heart? A study in myocardial preparations from cat hearts.奎尼丁对心脏的抗毒蕈碱作用？一项关于猫心心肌制剂的研究。
Br J Pharmacol. 1984 Jan;81(1):103-11. doi: 10.1111/j.1476-5381.1984.tb10749.x.
2
Pronounced cholinergic but only moderate purinergic effects in isolated atrial and ventricular heart muscle from cats.在猫的离体心房和心室心肌中，显示出明显的胆碱能效应，但嘌呤能效应仅为中等程度。
Br J Pharmacol. 1989 Aug;97(4):1191-8. doi: 10.1111/j.1476-5381.1989.tb12578.x.
3
Chronotropic and inotropic actions of amrinone, carbazeran and isobutylmethyl xanthine: role of phosphodiesterase inhibition.

本文引用的文献

1
Papaverine decreases the efflux of 42K in guinea-pig atrial heart muscle.罂粟碱可减少豚鼠心房肌中42K的外流。
Naunyn Schmiedebergs Arch Pharmacol. 1980 Jun;312(2):183-5. doi: 10.1007/BF00569728.
2
Elevation of guanosine 3',5'-cyclic phosphate in rat heart after perfusion with acetylcholine.乙酰胆碱灌注后大鼠心脏中环磷酸鸟苷的升高。
Proc Natl Acad Sci U S A. 1970 Jun;66(2):398-403. doi: 10.1073/pnas.66.2.398.
3
Effects of papaverine and its interaction with isoprenaline and carbachol on the contractile force and cyclic nucleotide levels of the canine ventricular myocardium.
氨力农、卡巴唑仑和异丁基甲基黄嘌呤的变时性和变力性作用：磷酸二酯酶抑制的作用
Br J Pharmacol. 1989 Sep;98(1):291-301. doi: 10.1111/j.1476-5381.1989.tb16894.x.
4
Adenosine inhibits the positive inotropic effect of 3-isobutyl-1-methylxanthine in papillary muscles without effect on cyclic AMP or cyclic GMP.腺苷可抑制3-异丁基-1-甲基黄嘌呤对乳头肌的正性肌力作用，而对环磷酸腺苷（cAMP）或环磷酸鸟苷（cGMP）无影响。
Br J Pharmacol. 1988 Apr;93(4):729-38. doi: 10.1111/j.1476-5381.1988.tb11456.x.
罂粟碱及其与异丙肾上腺素和卡巴胆碱的相互作用对犬心室心肌收缩力和环核苷酸水平的影响。
Naunyn Schmiedebergs Arch Pharmacol. 1979 Apr;306(3):241-8. doi: 10.1007/BF00507109.
4
Cyclic nucleotides and cardiac function.环核苷酸与心脏功能。
Circ Res. 1979 Feb;44(2):145-53. doi: 10.1161/01.res.44.2.145.
5
Muscarinic cholinergic receptor modulation of beta-adrenergic receptor affinity for catecholamines.
J Biol Chem. 1978 Jul 25;253(14):4833-6.
6
The inhibitory effect of papaverine on respiration-dependent contracture of giunea pig tainia coli in high-K medium. II. Inhibition of mitochondrial respiration.罂粟碱对高钾培养基中豚鼠结肠带呼吸依赖性挛缩的抑制作用。II. 对线粒体呼吸的抑制
Jpn J Pharmacol. 1977 Dec;27(6):845-53. doi: 10.1254/jjp.27.845.
7
Electrical and mechanical activity of mammalian heart fibres treated with papaverine. Interaction with isoprenaline and dibutyryl cyclic AMP.用罂粟碱处理的哺乳动物心脏纤维的电活动和机械活动。与异丙肾上腺素和二丁酰环磷酸腺苷的相互作用。
Naunyn Schmiedebergs Arch Pharmacol. 1977 Oct;299(3):253-8. doi: 10.1007/BF00500317.
8
Cyclid 3':5'-nucleotide phosphodiesterase. Interconvertible multiple forms and their effects on enzyme activity and kinetics.环化3':5'-核苷酸磷酸二酯酶。可相互转换的多种形式及其对酶活性和动力学的影响。
J Biol Chem. 1976 Sep 25;251(18):5726-37.
9
Cyclic AMP and cyclic GMP may play opposing roles in influencing force of contraction in mammalian myocardium.
Nature. 1976 Aug 5;262(5568):509-11. doi: 10.1038/262509b0.
10
Phosphodiesterases from porcine coronary arteries: inhibition of separated forms by xanthines, papaverine, and cyclic nucleotides.猪冠状动脉中的磷酸二酯酶：黄嘌呤、罂粟碱和环核苷酸对不同形式的抑制作用。
Mol Pharmacol. 1975 Nov;11(6):775-83.