Miyaki T, Tenmyo O, Numata K, Matsumoto K, Yamamoto H, Nishiyama Y, Ohbayashi M, Imanishi H, Konishi M, Kawaguchi H
J Antibiot (Tokyo). 1981 Jun;34(6):658-64. doi: 10.7164/antibiotics.34.658.
A series of new biosynthetic derivatives of tallysomycins A and B were obtained by precursor amine-feeding fermentation. Certain diamines were incorporated into tallysomycins as the terminal amine moiety affording two classes of biosynthetic derivatives, with or without the Beta-lysine moiety in the subterminal position. Among 21 derivatives prepared, tallysomycin S10b was selected for further studies in view of its favorable therapeutic indices.
通过前体胺进料发酵获得了一系列塔利霉素A和B的新生物合成衍生物。某些二胺作为末端胺部分掺入塔利霉素中，产生了两类生物合成衍生物，在亚末端位置有或没有β-赖氨酸部分。在制备的21种衍生物中，鉴于其良好的治疗指数，选择了塔利霉素S10b进行进一步研究。
