塔利索霉素，一种与博来霉素相关的新型抗肿瘤抗生素复合物。III. 塔利索霉素A和B的抗肿瘤活性。
Tallysomycin, a new antitumor antibiotic complex related to bleomycin. III. Antitumor activity of tallysomycins A and B.
作者信息
Imanishi H, Ohbayashi M, Nishiyama Y, Kawaguchi H
出版信息
J Antibiot (Tokyo). 1978 Jul;31(7):667-74. doi: 10.7164/antibiotics.31.667.
The antitumor activity of tallysomycins A and B was determined in five experimental tumor systems in mice. Tallysomycins A and B were highly active against B16 melanoma, sarcoma 180 ascites tumor and Lewis lung carcinoma, and moderately active against P388 leukemia but were without effect on lymphoid leukemia L1210. The antitumor activity of tallysomycin A was 2 to 3 times that of tallysomycin B and 3 to 17 times that of bleomycin. Tallysomycin A was about 1.5 and 4 times more toxic for mice than tallysomycin B and bleomycin, respectively, in terms of subacute LD50 values.
在五种小鼠实验肿瘤系统中测定了 tallysomycins A 和 B 的抗肿瘤活性。Tallysomycins A 和 B 对 B16 黑色素瘤、肉瘤 180 腹水瘤和 Lewis 肺癌具有高活性，对 P388 白血病具有中等活性，但对淋巴白血病 L1210 无作用。Tallysomycin A 的抗肿瘤活性是 tallysomycin B 的 2 至 3 倍，是博来霉素的 3 至 17 倍。就亚急性 LD50 值而言，Tallysomycin A 对小鼠的毒性分别比 tallysomycin B 和博来霉素高约 1.5 倍和 4 倍。
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