Rastogi S C, Clausen J
J Neurol Sci. 1981 Aug;51(2):161-9. doi: 10.1016/0022-510x(81)90095-2.
The present communication describes the ability of soluble enzymes (SE) of peripheral polymorphonuclear leucocytes of control and multiple sclerosis (MS) patients to degrade major myelin proteins of MS and control myelin. MS and control SE degraded in situ both Wolfgram protein (WP) and basic protein (BP) of isolated myelin. No differences were found between the action of control and MS patients SE on myelin. However, significantly less degradation of BP and WP in control myelin compared to that in MS myelin was found. Only 30% of SE samples (both control and MS) degraded significant amounts of proteolipid protein in myelin. It is postulated that SE associated demyelination in MS may be a factor contributing to the demyelinating process.
本通讯描述了对照组和多发性硬化症（MS）患者外周多形核白细胞的可溶性酶（SE）降解MS髓鞘和对照髓鞘主要髓磷脂蛋白的能力。MS和对照SE在原位降解了分离髓鞘的Wolfgram蛋白（WP）和碱性蛋白（BP）。对照和MS患者SE对髓鞘的作用未发现差异。然而，与MS髓鞘相比，对照髓鞘中BP和WP的降解明显较少。只有30%的SE样本（对照和MS）能显著降解髓鞘中的蛋白脂蛋白。据推测，MS中与SE相关的脱髓鞘可能是导致脱髓鞘过程的一个因素。
