Poletti C E, Cohen A M, Todd D P, Ojemann R G, Sweet W H, Zervas N T
J Neurosurg. 1981 Oct;55(4):581-4. doi: 10.3171/jns.1981.55.4.0581.
Clinical trials for abatement of intractable pelvic cancer pain were conducted in two patients, each electing surgical implantation of one of two indwelling catheter systems for administration of morphine into the spinal epidural space. Both systems, one consisting of a partially indwelling Broviac catheter, and the other, completely indwelling, consisting of a morphine reservoir connected to a shunt pump and on-off Hakim valve assembly, permitted the patients to return home where they could self-administer epidural morphine. Each patient reported that 2 mg of epidural morphine provided 8 to 12 hours of pain relief at a level of superior to their previous narcotic medication. On a regimen of 2 mg of epidural morphine administered twice daily, both patients experienced analgesia for 6 months, unaccompanied by alterations in sensory, motor, or cognitive functioning, and with a little drug tolerance reaction.
针对两名顽固性盆腔癌疼痛患者进行了临床试验，每名患者均选择通过手术植入两种留置导管系统之一，以便将吗啡注入脊髓硬膜外腔。两种系统中，一种由部分留置的Broviac导管组成，另一种完全留置，由连接分流泵和开关式哈金阀组件的吗啡储器组成，这两种系统使患者能够回家自行进行硬膜外吗啡给药。每名患者报告称，2毫克硬膜外吗啡提供的疼痛缓解时间为8至12小时，效果优于他们之前使用的麻醉药物。在每天两次给予2毫克硬膜外吗啡的治疗方案下，两名患者均经历了6个月的镇痛期，在此期间感觉、运动或认知功能未发生改变，且药物耐受反应轻微。
