Wren A, van Riezen H, Rigter H
Pharmakopsychiatr Neuropsychopharmakol. 1977 Mar;10(2):96-100. doi: 10.1055/s-0028-1094525.
Animal models presently in use for the screening of potential antidepressant drugs yield numerous false positives and false negatives. In search of a more specific model, we have studied the effects of psychotropic compounds on the behavioural changes induced in rats by the removal of the olfactory bulbs. We have observed that subchronic treatment with antidepressants in general reverses the behavioural alterations displayed by bulbectomized rats in tests of conditioned behaviour. The present paper describes a brief test, the so-called anxiosoif test, which may be used to assess the effects of drugs on the behaviour of bulbectomized rats. Removal of the olfactory bulbs leads to increased water intake in the anxiosoif test and to an attenuation of avoidance when the drinking spout is electrified. This latter effect can be reversed by subchronic treatment with the antidepressant drugs amitriptyline and mianserine (Org GB 94). It is suggested that the behavior of bulbectomized rats may be used as a specific tool in the prediction of antidepressant activity of novel compounds.
目前用于筛选潜在抗抑郁药物的动物模型会产生大量假阳性和假阴性结果。为了寻找更具特异性的模型，我们研究了精神药物对摘除嗅球的大鼠所诱导的行为变化的影响。我们观察到，一般而言，用抗抑郁药进行亚慢性治疗可逆转嗅球切除大鼠在条件行为测试中表现出的行为改变。本文描述了一种简短的测试，即所谓的焦虑嗅觉测试，该测试可用于评估药物对嗅球切除大鼠行为的影响。在焦虑嗅觉测试中，摘除嗅球会导致水摄入量增加，并且当饮水口带电时会减弱回避反应。后一种效应可通过用抗抑郁药物阿米替林和米安色林（Org GB 94）进行亚慢性治疗来逆转。有人提出，嗅球切除大鼠的行为可作为预测新型化合物抗抑郁活性的一种特异性工具。
