Maj J, Sowińska H, Baran L, Gancarczyk L, Rawłów A
Psychopharmacology (Berl). 1978 Sep 15;59(1):79-84. doi: 10.1007/BF00428035.
The central antiserotonergic action of mianserin (MS) was tested in mice, rats, and rabbits. MS, like cyproheptadine, to which it was compared, inhibits the head-twitch response to 5-hydroxytryptophan in mice and rats without affecting the pinna reflex. MS does not change the flexor reflex of the hind limb of the spinal rat; it antagonizes its stimulation induced by fenfluramine, LSD, and quipazine, but not that induced by clonidine. The hyperthermia in rabbits caused by the serotonergic stimulants cited above is also antagonized by pretreatment with MS. Unlike cyproheptadine, MS is not active in the oxotremorine test. The results indicate that at low doses MS is a central serotonergic-receptor blocker.
在小鼠、大鼠和兔子身上测试了米安色林（MS）的中枢抗血清素能作用。与所比较的赛庚啶一样，MS可抑制小鼠和大鼠对5-羟色氨酸的头部抽搐反应，而不影响耳廓反射。MS不会改变脊髓大鼠后肢的屈肌反射；它可拮抗芬氟拉明、麦角酸二乙胺和喹哌嗪诱导的该反射，但不能拮抗可乐定诱导的反射。上述血清素能兴奋剂引起的兔子体温过高也可通过MS预处理来拮抗。与赛庚啶不同，MS在毒蕈碱震颤试验中无活性。结果表明，低剂量时MS是一种中枢血清素能受体阻滞剂。
