Forsberg K, Sörenby L
Agents Actions. 1981 Jul;11(4):391-5. doi: 10.1007/BF01982476.
Groups of guinea pigs sensitized with ovalbumin were treated with budesonide and beclomethasone dipropionate, respectively, in an intraperitoneal dose of 50 mg/kg. 20 h later, the anaphylactic release of histamine and slow reacting substance of anaphylaxis (SRS-A) from chopped lung tissue was studied. Whereas the corticosteroids studied had no effect on the tissue content of histamine or on the amount of antigen-induced release of this autacoid, budesonide and beclomethasone dipropionate to a great extent inhibited the release of SRS-A. The anti-anaphylactic effect of budesonide and beclomethasone was also shown in sensitized guinea pigs pretreated with mepyramine, 2.5 mg/kg intraperitoneally, and challenged with nebulized ovalbumin. We suggest that the partial protection given by the corticosteroids budesonide and beclomethasone dipropionate is due to the inhibiton of SRS-A release.
用卵清蛋白致敏的豚鼠组分别用布地奈德和二丙酸倍氯米松以50mg/kg的腹腔内剂量进行治疗。20小时后，研究了切碎的肺组织中组胺和过敏反应慢反应物质（SRS-A）的过敏反应释放情况。虽然所研究的皮质类固醇对组胺的组织含量或该自分泌物质的抗原诱导释放量没有影响，但布地奈德和二丙酸倍氯米松在很大程度上抑制了SRS-A的释放。在用2.5mg/kg美吡拉敏腹腔内预处理并用雾化卵清蛋白激发的致敏豚鼠中，也显示了布地奈德和二丙酸倍氯米松的抗过敏作用。我们认为，皮质类固醇布地奈德和二丙酸倍氯米松提供的部分保护作用是由于对SRS-A释放的抑制。
