地塞米松和色甘酸钠对大鼠过敏性支气管收缩的抑制作用。
The inhibition by dexamethasone and disodium cromoglycate of anaphylactic bronchoconstriction in the rat.
作者信息
Church M K, Collier H O, James G W
出版信息
Br J Pharmacol. 1972 Sep;46(1):56-65. doi: 10.1111/j.1476-5381.1972.tb06848.x.
Abstract
- A method for the measurement of anaphylactic bronchoconstriction in the rat is described.2. Dexamethasone inhibited this response in a dose-related manner.3. Disodium cromoglycate antagonized the response. A bell-shaped dose-response curve was obtained with peak activity at 1 mg/kg i.v.4. Meclofenamate was not active when given alone or in combination with dexamethasone.5. Methysergide significantly inhibited the response. Mepyramine, atropine, propranolol and adrenalectomy did not significantly modify the response.6. The relationships of anaphylactic bronchoconstriction in the rat to anaphylactic bronchoconstriction in the guinea-pig and to human asthma are discussed.
摘要
描述了一种测量大鼠过敏性支气管收缩的方法。
地塞米松以剂量相关的方式抑制这种反应。
色甘酸钠拮抗该反应。静脉注射1mg/kg时获得钟形剂量反应曲线，活性峰值出现于此。
甲氯芬那酸单独给药或与地塞米松联合给药时均无活性。
麦角新碱显著抑制该反应。美吡拉敏、阿托品、普萘洛尔及肾上腺切除术均未显著改变该反应。
讨论了大鼠过敏性支气管收缩与豚鼠过敏性支气管收缩及人类哮喘之间的关系。
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