Seifertová M
Neoplasma. 1981;28(3):317-23.
The karyotype of AKR mouse lymphoblastic leukemia cell line made resistant to 5-azacytidine was compared with the karyotype of parental line. In relation of 5-azacytidine-resistant line the parental cell have less chromosomes No. 5 and more of No. 17 per karyogram. The increased monosomy has been found in chromosomes No. 5, 6, 7, 8 and 18 in sensitive line and in chromosomes No. 1, 8 and 17 in 5-azacytidine-resistant cells. The highest occurrence of trisomy was present in the chromosomes No. 13 and 16 in both lines. In AKR sensitive cells 89% of karyograms displayed 3 to 13 markers per karyogram while in the resistant line there were only 37% of karyograms with 1 to 11 markers.
将对5-氮杂胞苷产生抗性的AKR小鼠淋巴细胞白血病细胞系的核型与亲代细胞系的核型进行比较。与5-氮杂胞苷抗性细胞系相比，亲代细胞每个核型中的5号染色体较少，17号染色体较多。在敏感细胞系中，5号、6号、7号、8号和18号染色体出现了更多的单体，而在5-氮杂胞苷抗性细胞中，1号、8号和17号染色体出现了更多的单体。在两个细胞系中，13号和16号染色体的三体出现频率最高。在AKR敏感细胞中，89%的核型每个核型显示3至13个标记，而在抗性细胞系中，只有37%的核型具有1至11个标记。
