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[大肠杆菌中编码参与翻译的蛋白质的基因表达调控]

[Regulation of the expression of Escherichia coli genes coding for the proteins involved in translation].

作者信息

Grunberg-Manago M

出版信息

C R Seances Soc Biol Fil. 1981;175(4):426-45.

PMID:6170397
Abstract

We have described our present knowledge of the regulation of the expression of genes whose products are concerned with the protein biosynthesis in E. coli. In particular, we have discussed the mechanism of translational initiation which seems to be a crucial control point. Our own work on the organisation and regulation of the expression of a group of E. coli genes coding for initiation factor IF3 and two aminoacyl-tRNA synthetases was described in detail. This work illustrates the power of the new genetic engineering technology in studies on regulation at the molecular level.

摘要

我们已经阐述了目前对于大肠杆菌中与蛋白质生物合成相关的基因表达调控的认识。特别地，我们讨论了翻译起始机制，它似乎是一个关键的控制点。我们详细描述了自己关于一组编码起始因子IF3和两种氨酰-tRNA合成酶的大肠杆菌基因的表达组织和调控的研究工作。这项工作展示了新基因工程技术在分子水平调控研究中的强大作用。

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