Ulbright T M, Alexander R W, Kraus F T
Cancer. 1981 Nov 15;48(10):2260-6. doi: 10.1002/1097-0142(19811115)48:10<2260::aid-cncr2820481022>3.0.co;2-e.
A papillary tumor occurred in the posterior-superior vaginal wall of a 5-year-old girl who was free of recurrence one year following surgical excision. The light microscopic features included papillae lined by eosinophilic cells with uniform, bland nuclei, solid areas of identical cells, and scattered glandular lumina which contained mucopolysaccharides. Foci of eosinophilic hyaline globules were another distinctive feature. Electron microscopy of the tumor demonstrated features associated with müllerian neoplasms including projecting microvilli, whorls of perinuclear cytoplasmic microfilaments, conspicuous lysosomes, squamous metaplasia, complex cytoplasmic interdigitations, and pseudoinclusions of "cytoplasmic" collagen. Previously described "mesonephric papillomas" of the vagina and cervix are compared with the tumor of the authors' patient. The previously described tumors share some histologic and clinical features, although they were superficial rather than intramural proliferations. The authors conclude that the ultrastructure, location, and documented presence of müllerian structures in the vagina favor a müllerian origin for this vaginal tumor. A number of other vaginal tumors that occur in children and young women show different light microscopic features.
一名5岁女童阴道后壁出现乳头状肿瘤，手术切除后1年无复发。光镜下特征包括：乳头由嗜酸性细胞衬覆，细胞核均匀、温和，有相同细胞构成的实性区域，散在的腺腔含有黏多糖。嗜酸性透明小球灶是另一个显著特征。肿瘤的电镜检查显示出与苗勒氏肿瘤相关的特征，包括突出的微绒毛、核周胞质微丝的漩涡、明显的溶酶体、鳞状化生、复杂的胞质交错以及“胞质”胶原的假包涵体。将先前描述的阴道和宫颈“中肾乳头状瘤”与作者患者的肿瘤进行比较。先前描述的肿瘤有一些组织学和临床特征，尽管它们是浅表性而非壁内增殖。作者得出结论，该阴道肿瘤的超微结构、位置以及阴道中苗勒氏结构的存在支持其来源于苗勒氏组织。儿童和年轻女性中发生的许多其他阴道肿瘤表现出不同的光镜特征。
