Tenner T E, Yang C M, Chang J K, Schimizu M, Pang P K
Peptides. 1980 Winter;1(4):285-8. doi: 10.1016/0196-9781(80)90004-2.
The purpose of the present study was to compare the potency, effectiveness and duration of action of synthetic bPTH-(1-34) with those of other known hypotensive peptides in the anesthetized dog. Of sixteen peptides tested in the present study only 8 were demonstrated to possess hypotensive activity. While bPTh-(1-34) was one of the least potent of the hypotensive peptides, it was equal to or greater than the other peptides in terms of effectiveness and duration of action. Of all the peptides studied, substance P and eledosin were the most potent in terms of their hypotensive action. It is suggested that perhaps substance P and eledoisin might act at a different site or through different mechanisms than do vasoactive intestinal peptide (V.I.P.), corticotropin inhibiting peptide (C.I.P.), neurotensin, xenopsin, bradykinin and bPTH-(1-34).
本研究的目的是比较合成的bPTH-(1-34)与其他已知降压肽在麻醉犬体内的效价、有效性和作用持续时间。在本研究中测试的16种肽中，只有8种被证明具有降压活性。虽然bPTh-(1-34)是降压肽中效价最低的之一，但在有效性和作用持续时间方面与其他肽相当或更高。在所有研究的肽中，P物质和依地多辛在降压作用方面效价最高。有人认为，P物质和依地多辛可能与血管活性肠肽（V.I.P.）、促肾上腺皮质激素抑制肽（C.I.P.）、神经降压素、异视紫质、缓激肽和bPTH-(1-34)作用于不同的部位或通过不同的机制起作用。
