Yang M C, Tenner T E, Pang P K
Pharmacology. 1981;22(5):305-10. doi: 10.1159/000137505.
Promethazine and cimetidine blocked the hypotensive actions of 2-pyridylethylamine, and H1 agonist and dimaprit, an H2 agonist, respectively, but not that of bovine parathyroid hormone fragment [bPTH-(1-34)]. Rats were treated repeatedly with the histamine releaser, compound 48/80, until the release could no longer produce a decrease in blood pressure. The hypotensive action of bPTH-(1-34) could still be seen. Rats with histamine partially depleted with one injection of compound 48/80 were injected with cimetidine and pyrilamine, and H1 antagonist, which together blocked the hypotensive action of subsequent injections of compound 48/80, but not that of bPTH-(1-34). These data suggest that the vasodilatory action of bPTH-(1-34) does not involve the release or action of histamine.
异丙嗪和西咪替丁分别阻断了2-吡啶乙胺、H1激动剂和H2激动剂二甲双胍的降压作用，但未阻断牛甲状旁腺激素片段[bPTH-(1-34)]的降压作用。用组胺释放剂化合物48/80反复处理大鼠，直到释放不再导致血压下降。仍可观察到bPTH-(1-34)的降压作用。用一次化合物48/80使组胺部分耗竭的大鼠注射西咪替丁和H1拮抗剂吡拉明，它们共同阻断了随后注射化合物48/80的降压作用，但未阻断bPTH-(1-34)的降压作用。这些数据表明，bPTH-(1-34)的血管舒张作用不涉及组胺的释放或作用。
