Kundin W D, Mechali P, Hollinshead A C, Bensimon H, Miller H
Prostate. 1981;2(2):207-17. doi: 10.1002/pros.2990020209.
A satisfactory, simple test for screening and monitoring of patients with prostatic cancer is still being sought. We suggest the use of a nonspecific test in combination with other tests. The ratio of two serum proteins (alpha 1 acid glycoprotein [AGP] and prealbumin [PAB]), may be useful markers for a cancer serum index (CSI). By separating serum components by gradient polyacrylamide gel electrophoresis, staining and quantitating these proteins by scanning densitometry, and dividing the area of AGP by that of PAB, indices can be obtained. In a test of sera from 450 patients with prostatic cancer, other urologic problems, and normal controls, CSIs of 360 sera presently decoded were found to be: (Formula: see text). The CSI should prove highly valuable when used in combination with selected prostatic cancer tests.
目前仍在寻找一种令人满意的、简单的用于筛查和监测前列腺癌患者的检测方法。我们建议将一种非特异性检测与其他检测结合使用。两种血清蛋白（α1酸性糖蛋白[AGP]和前白蛋白[PAB]）的比值可能是癌症血清指数（CSI）的有用标志物。通过梯度聚丙烯酰胺凝胶电泳分离血清成分，用扫描密度计对这些蛋白质进行染色和定量，并将AGP的面积除以PAB的面积，即可获得指数。在对450例前列腺癌患者、其他泌尿系统疾病患者和正常对照者的血清进行检测时，目前解码的360份血清的CSI为：（公式：见正文）。当与选定的前列腺癌检测方法结合使用时，CSI应被证明具有很高的价值。
