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耗氧量降低和心率下降作为小鼠肥胖-高血糖综合征(ob/ob)的早期症状。

Lowered oxygen consumption and heart rate as early symptoms of the obese-hyperglycemic syndrome in mice (ob/ob).

作者信息

van der Kroon H W, van Vroonhoven T M, Douglas L T

出版信息

Int J Obes. 1977;1(4):325-30.

PMID:617113
Abstract

Latent obese-hyperglycemic mice exhibit significantly subnormal heart rate and level of oxygen consumption as early as three and eight days post-partum, respectively. Also, loss of body weight during a three-hour fasting period is detectably less extreme in obese than in normal litter mates as early as five days post-partum. Regression analysis of the differences between the latent obese and normal litter mates suggests that these symptoms begin developing at birth.

摘要

潜在肥胖高血糖小鼠分别在产后三天和八天就出现明显低于正常水平的心率和耗氧量。此外,早在产后五天,肥胖小鼠在三小时禁食期间的体重减轻程度就明显低于正常同窝小鼠。对潜在肥胖小鼠和正常同窝小鼠差异的回归分析表明,这些症状在出生时就开始出现。

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Lowered oxygen consumption and heart rate as early symptoms of the obese-hyperglycemic syndrome in mice (ob/ob).耗氧量降低和心率下降作为小鼠肥胖-高血糖综合征(ob/ob)的早期症状。
Int J Obes. 1977;1(4):325-30.
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引用本文的文献

1
Obesity: do fat cells from genetically obese mice (C57BL/6J ob/ob) have an innate capacity for increased fat storage?肥胖:来自遗传性肥胖小鼠(C57BL/6J ob/ob)的脂肪细胞是否具有增加脂肪储存的先天能力?
Diabetologia. 1978 Dec;15(6):465-70. doi: 10.1007/BF02342871.