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肥胖:来自遗传性肥胖小鼠(C57BL/6J ob/ob)的脂肪细胞是否具有增加脂肪储存的先天能力?

Obesity: do fat cells from genetically obese mice (C57BL/6J ob/ob) have an innate capacity for increased fat storage?

作者信息

Ashwell M, Meade C J

出版信息

Diabetologia. 1978 Dec;15(6):465-70. doi: 10.1007/BF02342871.

Abstract

Fat tissue from the genetically obese mouse (C57BL/6J ob/ob) and its lean littermate (+/?) was transplanted into lean hosts(+/+). Chemical induced obesity in the host mice caused no greater increase in the size of 'obese' fat cells than it did in the size of 'lean' fat cells. 'Obese' fat cells, therefore, have no innate capacity for increased fat storage.

摘要

将基因肥胖小鼠(C57BL/6J ob/ob)及其瘦型同窝小鼠(+/?)的脂肪组织移植到瘦型宿主(+/+)体内。宿主小鼠化学诱导肥胖后,“肥胖”脂肪细胞大小的增加幅度并不比“瘦”脂肪细胞的增加幅度更大。因此,“肥胖”脂肪细胞没有增加脂肪储存的内在能力。

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