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肥胖：来自遗传性肥胖小鼠（C57BL/6J ob/ob）的脂肪细胞是否具有增加脂肪储存的先天能力？

Obesity: do fat cells from genetically obese mice (C57BL/6J ob/ob) have an innate capacity for increased fat storage?

作者信息

Ashwell M, Meade C J

出版信息

Diabetologia. 1978 Dec;15(6):465-70. doi: 10.1007/BF02342871.

DOI:10.1007/BF02342871
PMID:363493
Abstract

Fat tissue from the genetically obese mouse (C57BL/6J ob/ob) and its lean littermate (+/?) was transplanted into lean hosts(+/+). Chemical induced obesity in the host mice caused no greater increase in the size of 'obese' fat cells than it did in the size of 'lean' fat cells. 'Obese' fat cells, therefore, have no innate capacity for increased fat storage.

摘要

将基因肥胖小鼠（C57BL/6J ob/ob）及其瘦型同窝小鼠（+/？）的脂肪组织移植到瘦型宿主（+/+）体内。宿主小鼠化学诱导肥胖后，“肥胖”脂肪细胞大小的增加幅度并不比“瘦”脂肪细胞的增加幅度更大。因此，“肥胖”脂肪细胞没有增加脂肪储存的内在能力。

相似文献

1
Obesity: do fat cells from genetically obese mice (C57BL/6J ob/ob) have an innate capacity for increased fat storage?肥胖：来自遗传性肥胖小鼠（C57BL/6J ob/ob）的脂肪细胞是否具有增加脂肪储存的先天能力？
Diabetologia. 1978 Dec;15(6):465-70. doi: 10.1007/BF02342871.
2
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Proc R Soc Lond B Biol Sci. 1979 Aug 31;205(1160):395-410. doi: 10.1098/rspb.1979.0073.
3
Brown adipose tissue: contributions of nature and nurture to the obesity of an obese mutant mouse (ob/ob).棕色脂肪组织：先天与后天因素对肥胖突变小鼠（ob/ob）肥胖的影响
Int J Obes. 1986;10(5):355-73.
4
The use of the adipose tissue transplantation technique to demonstrate that abnormalities in the adipose tissue metabolism of genetically obese mice are due to extrinsic rather than intrinsic factors.利用脂肪组织移植技术来证明，遗传性肥胖小鼠脂肪组织代谢异常是由外在因素而非内在因素导致的。
Int J Obes. 1985;9 Suppl 1:77-82.
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Obesity: can some fat cells enlarge while others are shrinking?肥胖：是否有些脂肪细胞在增大而另一些在缩小？
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6
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Endocrinology. 2000 Sep;141(9):3388-96. doi: 10.1210/endo.141.9.7637.
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Fatty acid composition of triglycerides from adipose tissue transplanted between obese and lean mice.肥胖小鼠和瘦小鼠之间移植的脂肪组织中甘油三酯的脂肪酸组成。
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Effects of genetic and diet-induced obesity on lipid metabolism.基因和饮食诱导的肥胖对脂质代谢的影响。
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本文引用的文献

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Obesity in albino mice due to single injections of goldthioglucose.单次注射金硫葡萄糖导致白化小鼠肥胖。
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Fatty acid composition of triglycerides from adipose tissue transplanted between obese and lean mice.肥胖小鼠和瘦小鼠之间移植的脂肪组织中甘油三酯的脂肪酸组成。
Lipids. 1983 Nov;18(11):776-80. doi: 10.1007/BF02534635.
7
Establishment of a preadipocyte cell line from the epididymal fat pad of the lean C57 BL/6J mouse--long term effects of insulin and triiodothyronine on adipose conversion.从瘦型C57 BL/6J小鼠附睾脂肪垫建立前脂肪细胞系——胰岛素和三碘甲状腺原氨酸对脂肪转化的长期影响
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4
Lipoprotein lipase activities in tissues of normal and genetically obese (ob-ob) mice.正常小鼠和遗传性肥胖（ob-ob）小鼠组织中的脂蛋白脂肪酶活性。
Diabetologia. 1974 Aug;10(4):261-5. doi: 10.1007/BF03654924.
5
Role of the thyroid in the development of the obese-hyperglycemic syndrome in mice (ob ob).甲状腺在小鼠肥胖-高血糖综合征（ob ob）发展中的作用
Metabolism. 1974 May;23(5):425-36. doi: 10.1016/0026-0495(74)90090-0.
6
Human fat cell sizing--a quick, simple method.人体脂肪细胞大小测定——一种快速、简便的方法。
J Lipid Res. 1976 Mar;17(2):190-2.
7
Thermogenic defect in pre-obese ob/ob mice.肥胖前期ob/ob小鼠的产热缺陷
Nature. 1977 Mar 3;266(5597):60-2. doi: 10.1038/266060a0.
8
Laboratory animals exhibiting obesity and diabetes syndromes.表现出肥胖和糖尿病综合征的实验动物。
Metabolism. 1977 Jan;26(1):59-99. doi: 10.1016/0026-0495(77)90128-7.
9
The development of obesity in preweaning obob mice.断奶前obob小鼠肥胖症的发展
Br J Nutr. 1978 Mar;39(2):397-402. doi: 10.1079/bjn19780050.
10
Lowered oxygen consumption and heart rate as early symptoms of the obese-hyperglycemic syndrome in mice (ob/ob).耗氧量降低和心率下降作为小鼠肥胖-高血糖综合征（ob/ob）的早期症状。
Int J Obes. 1977;1(4):325-30.