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霍奇金病中提示细胞壁缺陷菌的不同抗酸球状形态的组织学观察:4例报告

Histologic observations of variably acid-fast coccoid forms suggestive of cell wall deficient bacteria in Hodgkin's disease: a report of four cases.

作者信息

Cantwell A R

出版信息

Growth. 1981 Autumn;45(3):168-87.

PMID:6171483
Abstract

The microscopic sections of biopsy material derived from four patients diagnosed at having Hodgkin's disease (HD), including two necropsied cases, were all studied for the presence of acid-fast cell wall deficient (CWD) bacteria. Variably acid-fast and variably sized coccoid forms, suggestive of CWD bacteria, were observed in the pathologically altered tissue and also in some histologically "normal" microscopic sections. This findings of bacteria in vivo in HD may relate to the previously reported findings of cocci, non-acid-fast and acid-fast bacteria (especially Mycobacterium tuberculosis) in HD, and may also relate to the previously reported findings of similar microbes in certain neoplastic, lymphoproliferative, and collagen diseases.

摘要

对4例被诊断为霍奇金病(HD)患者的活检材料进行显微镜切片研究,其中包括2例尸检病例,以检测抗酸细胞壁缺陷(CWD)细菌的存在。在病理改变的组织以及一些组织学上“正常”的显微镜切片中,均观察到了大小不一、抗酸性各异的类球菌形态,提示可能存在CWD细菌。HD患者体内细菌的这一发现可能与先前报道的HD中球菌、非抗酸菌和抗酸菌(尤其是结核分枝杆菌)的发现有关,也可能与先前报道的某些肿瘤性、淋巴增殖性和胶原疾病中类似微生物的发现有关。

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