Cantwell A R, Cove J K
Cutis. 1984 Jun;33(6):560-7.
A 41-year-old woman with chronic systemic lupus erythematosus (SLE), uncomplicated by sepsis or other "secondary infection," died of an acute myocardial infarction. All of the available necroscopic material was reviewed to determine whether acid-fast cell wall deficient bacteria (CWDB) could be demonstrated in vivo. Variably acid-fast coccoid forms, suggestive of CWDB, were observed in specially-stained (intensified Kinyoun acid-fast stain) microscopic sections of the heart, lungs, kidney, adrenal glands, brain, connective tissue, and other organs. Acid-fast "hematoxylin bodies" were also observed. The finding of variably acid-fast bacteria in postmortem tissue in SLE may relate to the current finding of variably acid-fast CWDB within the blood stream of "normal" and diseased persons. In addition, the finding of acid-fast bacteria may relate to the previous reports of similar bacteria in scleroderma, pseudoscleroderma, and cutaneous lesions of SLE. The further search for CWDB in necropsied cases of SLE may elucidate the possible pathogenic role, if any, of these microbes in SLE.
一名41岁患有慢性系统性红斑狼疮（SLE）且未并发败血症或其他“继发性感染”的女性死于急性心肌梗死。对所有可用的尸检材料进行了检查，以确定是否能在体内发现抗酸细胞壁缺陷菌（CWDB）。在心脏、肺、肾脏、肾上腺、大脑、结缔组织和其他器官的特殊染色（强化金扬抗酸染色）显微切片中观察到了形态各异的抗酸性球菌样形态，提示为CWDB。还观察到了抗酸性“苏木精小体”。SLE患者死后组织中发现形态各异的抗酸菌可能与目前在“正常”人和患病者血流中发现形态各异的抗酸CWDB有关。此外，抗酸菌的发现可能与先前在硬皮病、假硬皮病和SLE皮肤病变中关于类似细菌的报道有关。在SLE尸检病例中进一步寻找CWDB可能会阐明这些微生物在SLE中可能存在的致病作用（如果有的话）。
