Szpak C A, Creasman W T, Vollmer R T, Johnston W W
Acta Cytol. 1981 Nov-Dec;25(6):640-6.
Peritoneal pelvic washings from 54 women with pathologic stage I endometrial carcinoma were evaluated in a blind retrospective fashion for the concentration of malignant cells present. None of the 42 patients with normal washings developed recurrence after a median disease-free survival of 36 months. Of the 12 patients with adenocarcinoma in the washings, 4 had high concentrations of malignant cells (greater than 1000 cells/100 ml sample), and all 4 died as a consequence of carcinoma within two years. The remaining eight patients had lower concentrations of malignant cells in the washings (less than 1000 cells/100 ml sample), and six of these patients had no evidence of disease after 37 to 64 months. Cox's nonparametric statistical model showed that increasing concentrations of adenocarcinoma cells in washings significantly shortened the time to recurrence of disease. The abundance of malignant cells has prognostic importance in identifying those patients with pathologic stage I disease who may require more aggressive therapy.
对54例病理分期为I期子宫内膜癌女性的盆腔腹膜冲洗液进行了盲法回顾性评估，以确定其中存在的恶性细胞浓度。42例冲洗液正常的患者在无病生存期中位数为36个月后均未复发。冲洗液中存在腺癌的12例患者中，4例恶性细胞浓度高（大于1000个细胞/100 ml样本），这4例患者均在两年内因癌症死亡。其余8例患者冲洗液中恶性细胞浓度较低（小于1000个细胞/100 ml样本），其中6例患者在37至64个月后无疾病证据。Cox非参数统计模型显示，冲洗液中腺癌细胞浓度增加会显著缩短疾病复发时间。恶性细胞的数量对于识别那些可能需要更积极治疗的病理I期疾病患者具有预后意义。
