Franco D, Morin J, Szekely A M, Bismuth H
Biomedicine. 1981 Oct;35(5):162-5.
Conflicting results have been reported on the influence of portacaval anastomosis on liver carcinogenesis. The purpose of this investigation was to study the effect of portal diversion on liver carcinogenesis induced in the rat by a potent chemical liver carcinogen, Aflatoxin B1 (AFB1). Liver tumors appeared earlier and were significantly bigger in rats with shunts than in sham-operated controls. Portal diversion also induced in rats fed AFB1 a splenic atrophy with nearly complete disappearance of Malpighian corpuscles suggesting a profound immunodepression. This might be responsible for the enhancement of liver cancer by portacaval anastomosis in the rats fed AFB1. Thus, the influence of portal diversion on liver cancers appears to be multifactorial.
关于门腔静脉吻合术对肝癌发生的影响，已有相互矛盾的研究结果报道。本研究的目的是探讨门脉分流对由强效化学性肝致癌物黄曲霉毒素B1（AFB1）诱发的大鼠肝癌发生的影响。与假手术对照组相比，行分流术的大鼠肝脏肿瘤出现得更早且明显更大。门脉分流还导致喂食AFB1的大鼠出现脾萎缩，脾小结几乎完全消失，提示存在严重的免疫抑制。这可能是喂食AFB1的大鼠门腔静脉吻合术促进肝癌发生的原因。因此，门脉分流对肝癌的影响似乎是多因素的。
