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大鼠门腔静脉转位及随后的部分肝切除术：对肝脏萎缩、肥大和再生性增生的影响

Portacaval transposition and subsequent partial hepatectomy in the rat: effects on liver atrophy, hypertrophy and regenerative hyperplasia.

作者信息

Guest J, Ryan C J, Benjamin I S, Blumgart L H

出版信息

Br J Exp Pathol. 1977 Apr;58(2):140-6.

PMID:861164
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2041272/
Abstract

Portacaval transposition diverts portal blood from the liver. It allows systemic venous blood to perfuse the portal bed. Body weight and liver weight have been followed before and after portacaval transposition and control procedures in rats, and the DNA activity ratio studied in the liver of rats after partial hepatectomy in protacavally transposed animals. The results suggest that the liver atrophy seen after portal diversion is a result of diversion of trophic substances in the portal blood rather than of a decrease in absolute liver flow. Recovery of liver weight after partial hepatectomy in portacavally transposed animals occurs within the same time as in control animals, and the time course and magnitude of regenerative hyperplasia, as assessed by liver DNA activity ratio, is unimpaired.

摘要

门腔静脉转位使门静脉血从肝脏分流。它允许体循环静脉血灌注门静脉床。在大鼠进行门腔静脉转位及对照手术前后，对大鼠的体重和肝脏重量进行了跟踪，并对门腔静脉转位动物部分肝切除术后肝脏的DNA活性比进行了研究。结果表明，门静脉分流后出现的肝脏萎缩是门静脉血中营养物质分流的结果，而非肝脏绝对血流量减少所致。门腔静脉转位动物部分肝切除术后肝脏重量的恢复与对照动物在相同时间内发生，并且通过肝脏DNA活性比评估的再生性增生的时间进程和程度未受损害。

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Portacaval transposition and subsequent partial hepatectomy in the rat: effects on liver atrophy, hypertrophy and regenerative hyperplasia.大鼠门腔静脉转位及随后的部分肝切除术：对肝脏萎缩、肥大和再生性增生的影响
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本文引用的文献

1
Diurnal mitotic periodicity in regenerating rat liver.再生大鼠肝脏中的昼夜有丝分裂周期性
Anat Rec. 1954 Dec;120(4):935-54. doi: 10.1002/ar.1091200408.
2
REGENERATION OF MAMMALIAN LIVER.哺乳动物肝脏的再生
Int Rev Cytol. 1963;15:245-300. doi: 10.1016/s0074-7696(08)61119-5.
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DELAYED INCORPORATION OF 32P FROM ORTHOPHOSPHATE INTO DEOXYRIBONUCLEIC ACID OF RAT LIVER AFTER SUBTOTAL HEPATECTOMY.肝大部切除术后大鼠肝脏中32P从正磷酸盐延迟掺入脱氧核糖核酸的情况
Br J Exp Pathol. 1964 Aug;45(4):442-9.
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Studies on hepatic blood flow and the rate of bromsulphalein clearance in dogs with portacaval transposition.门腔静脉转位犬肝脏血流及溴磺酞钠清除率的研究。
Surgery. 1962 Oct;52:660-3.
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Liver regeneration following portacaval shunt.
Surgery. 1962 Jul;52:88-102.
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The relation between hepatic flow and function in normal dogs and dogs with cirrhosis after portacaval shunt or transposition.正常犬以及门腔静脉分流或转位后肝硬化犬的肝血流与肝功能之间的关系。
Surg Forum. 1960;11:282-4.
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The portal blood supply and regeneration of the rat liver.大鼠肝脏的门静脉血供与再生
Br J Exp Pathol. 1955 Dec;36(6):583-91.
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The effects of cortisol and chlorazanil on the mitotic rate in mouse liver and skin.皮质醇和氯扎尼对小鼠肝脏和皮肤有丝分裂率的影响。
Eur J Cancer (1965). 1966 Aug;2(3):227-30. doi: 10.1016/0014-2964(66)90058-2.
9
Increased incorporation of 3H-thymidine into rat liver DNA after handling of liver lobes.处理肝叶后，大鼠肝脏DNA中3H-胸腺嘧啶核苷的掺入增加。
Br J Exp Pathol. 1969 Dec;50(6):540-7.
10
The development of a proliferative response in liver parenchyma deprived of portal blood flow.在缺乏门静脉血流的肝实质中增殖反应的发展。
Br J Exp Pathol. 1972 Feb;53(1):54-8.

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