睾丸癌中α-甲胎蛋白和人绒毛膜促性腺激素的体外合成
In vitro synthesis of alpha-fetoprotein and human chorionic gonadotropin in testicular cancer.
作者信息
Javadpour N, Soares T, Princler G L
出版信息
Cancer. 1982 Jan 15;49(2):303-7. doi: 10.1002/1097-0142(19820115)49:2<303::aid-cncr2820490216>3.0.co;2-m.
Abstract
In vitro synthesis of alpha-fetoprotein (AFP) and human chorionic gonadotropin (HCG) utilizing 14C-L-leucine and 14C-L-lysine incorporation in fresh testicular cancer tissue of five patients was demonstrated. Radioimmunoassay, immunoprecipitation of 14C-HCG and 14C-AFP, and quantitation of AFP and HCG. This in vitro synthesis of AFP and HCG was correlated with immunocytochemical staining in the cancer cells of the five patients.
摘要
利用14C-L-亮氨酸和14C-L-赖氨酸掺入五例新鲜睾丸癌组织中，证明了体外合成甲胎蛋白（AFP）和人绒毛膜促性腺激素（HCG）。进行放射免疫测定、14C-HCG和14C-AFP的免疫沉淀以及AFP和HCG的定量分析。AFP和HCG的这种体外合成与五例患者癌细胞中的免疫细胞化学染色相关。
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